Type I Interferon: A New Player in TNF Signaling

Curr Dir Autoimmun. 2010;11:94-104. doi: 10.1159/000289199. Epub 2010 Feb 18.

Abstract

TNF and type I interferons (IFNs) are induced by microbial stimuli and mediate innate immune responses. They are also involved in the pathogenesis of chronic inflammatory diseases, such as rheumatoid arthritis and systemic lupus erythematosus. Activated macrophages are an important driving force of inflammatory reactions and one of the major producers of TNF in innate immunity and chronic inflammation. Despite the fact that cells at sites of damage are continuously exposed to both cytokines, little is known about mechanisms regulating TNF and type I IFN interactions during inflammation. In this review, we discuss the role of an IFN-beta-mediated autocrine loop in the regulation of gene expression program induced by TNF in myeloid cells.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Autocrine Communication / immunology
  • Gene Expression
  • Humans
  • Immunity, Innate / genetics
  • Interferon Type I / biosynthesis
  • Interferon Type I / immunology*
  • Models, Immunological
  • NF-kappa B / immunology
  • Signal Transduction / immunology
  • Toll-Like Receptors / immunology
  • Tumor Necrosis Factor-alpha / immunology*

Substances

  • Interferon Type I
  • NF-kappa B
  • Toll-Like Receptors
  • Tumor Necrosis Factor-alpha