Delineation of the nucleus centre median by proton density weighted magnetic resonance imaging at 3 T

Oper Neurosurg (Hagerstown). 2010 Mar;66(suppl_1):ons-E121-ons-E123. doi: 10.1227/01.NEU.0000348560.85056.63.


Objective: To demonstrate that proton density weighted magnetic resonance imaging (MRI) at 3 T accomplishes delineation of the centre median (CM) complex from surrounding thalamic tissue and may improve targeting accuracy in stereotactic neurosurgery.

Methods: Five healthy subjects (1 man, 4 women; age range 22-35 years) underwent high-resolution MRI at 3 T with different imaging parameters in order to optimize the direct visualization of the CM.

Results: In healthy subjects, the CM complex of the thalamus can be reliably contrasted on axially oriented slices by means of proton density weighted turbo-spin-echo MRI. An in-plane resolution of at least 0.6 x 0.6 mm2 is crucial at a slice thickness between 2 and 3 mm. Effective suppression of head motion is essential.

Conclusion: MRI-based delineation of the CM could have therapeutic potential to facilitate target determination for neuromodulation in stereotactic neurosurgery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain Mapping / methods*
  • Female
  • Humans
  • Intralaminar Thalamic Nuclei / anatomy & histology*
  • Intralaminar Thalamic Nuclei / surgery
  • Magnetic Resonance Imaging / methods*
  • Male
  • Neuronavigation / methods
  • Preoperative Care / methods
  • Stereotaxic Techniques
  • Thalamus / anatomy & histology*
  • Thalamus / surgery
  • Young Adult