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. 2010 Aug;52(8):729-33.
doi: 10.1007/s00234-010-0653-1. Epub 2010 Feb 20.

Diffusion tensor tract-specific analysis of the uncinate fasciculus in patients with amyotrophic lateral sclerosis

Kanako Sato  1 , Shigeki Aoki, Nobue K Iwata, Yoshitaka Masutani, Takeyuki Watadani, Yasuhiro Nakata, Mariko Yoshida, Yasuo Terao, Osamu Abe, Kuni Ohtomo, Shoji Tsuji
Affiliations

Diffusion tensor tract-specific analysis of the uncinate fasciculus in patients with amyotrophic lateral sclerosis

Kanako Sato et al. Neuroradiology. 2010 Aug.

Abstract

Introduction: The uncinate fasciculus (UF) consists of core fibers connecting the frontal and temporal lobes and is considered to be related to cognitive/behavioral function. Using diffusion tensor tractography, we quantitatively evaluated changes in fractional anisotropy (FA) and the apparent diffusion coefficient (ADC) of the UF by tract-specific analysis to evaluate the damage of the UF in patients with amyotrophic lateral sclerosis (ALS).

Methods: We obtained diffusion tensor images of 15 patients with ALS and 9 age-matched volunteers.

Results: Patients with ALS showed significantly lower mean FA (P = 0.029) compared with controls. No significant difference was seen in mean ADC.

Conclusion: The results suggest that damage of the UF in patients with ALS can be quantitatively evaluated with FA.

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