Effects of exercise on hepcidin response and iron metabolism during recovery

Int J Sport Nutr Exerc Metab. 2009 Dec;19(6):583-97. doi: 10.1123/ijsnem.19.6.583.

Abstract

Urinary hepcidin, inflammation, and iron metabolism were examined during the 24 hr after exercise. Eight moderately trained athletes (6 men, 2 women) completed a 60-min running trial (15-min warm-up at 75-80% HR(peak) + 45 min at 85-90% HR(peak)) and a 60-min trial of seated rest in a randomized, crossover design. Venous blood and urine samples were collected pretrial, immediately posttrial, and at 3, 6, and 24 hr posttrial. Samples were analyzed for interleukin-6 (IL-6), C-reactive protein (CRP), serum iron, serum ferritin, and urinary hepcidin. The immediate postrun levels of IL-6 and 24-hr postrun levels of CRP were significantly increased from baseline (6.9 and 2.6 times greater, respectively) and when compared with the rest trial (p < or = .05). Hepcidin levels in the run trial after 3, 6, and 24 hr of recovery were significantly greater (1.7-3.1 times) than the pre- and immediate postrun levels (p < or = .05). This outcome was consistent in all participants, despite marked variation in the magnitude of rise. In addition, the 3-hr postrun levels of hepcidin were significantly greater than at 3 hr in the rest trial (3.0 times greater, p < or = .05). Hepcidin levels continued to increase at 6 hr postrun but failed to significantly differ from the rest trial (p = .071), possibly because of diurnal influence. Finally, serum iron levels were significantly increased immediately postrun (1.3 times, p < or = .05). The authors concluded that high-intensity exercise was responsible for a significant increase in hepcidin levels subsequent to a significant increase in IL-6 and serum iron.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Bacterial Agents / urine*
  • Antimicrobial Cationic Peptides / urine*
  • C-Reactive Protein / metabolism
  • Cross-Over Studies
  • Female
  • Ferritins / blood
  • Hepcidins
  • Humans
  • Inflammation / blood
  • Interleukin-6 / blood
  • Iron / blood*
  • Iron / deficiency
  • Male
  • Postprandial Period
  • Running / physiology*

Substances

  • Anti-Bacterial Agents
  • Antimicrobial Cationic Peptides
  • HAMP protein, human
  • Hepcidins
  • Interleukin-6
  • C-Reactive Protein
  • Ferritins
  • Iron