Lactic acid bacteria as adjuvants for sublingual allergy vaccines

Vaccine. 2010 Apr 9;28(17):2986-92. doi: 10.1016/j.vaccine.2010.02.009. Epub 2010 Feb 20.


We compared immunomodulatory properties of 11 strains of lactic acid bacteria as well as their capacity to enhance sublingual immunotherapy efficacy in a murine asthma model. Two types of bacterial strains were identified, including: (i) potent inducers of IL-12p70 and IL-10 in dendritic cells, supporting IFN-gamma and IL-10 production in CD4+ T cells such as Lactobacillus helveticus; (ii) pure Th1 inducers such as L. casei. Sublingual administration in ovalbumin-sensitized mice of L. helveticus, but not L. casei, reduced airways hyperresponsiveness, bronchial inflammation and proliferation of specific T cells in cervical lymph nodes. Thus, probiotics acting as a Th1/possibly Treg, but not Th1 adjuvant, potentiate tolerance induction via the sublingual route.

MeSH terms

  • Adjuvants, Immunologic / administration & dosage*
  • Administration, Sublingual
  • Allergens / immunology
  • Animals
  • Asthma / immunology
  • Asthma / prevention & control*
  • Female
  • Immune Tolerance
  • Lactobacillus / immunology*
  • Lymph Nodes / immunology
  • Mice
  • Mice, Inbred BALB C
  • Ovalbumin / immunology
  • Probiotics / administration & dosage*
  • T-Lymphocytes, Regulatory / immunology
  • Vaccines / administration & dosage*
  • Vaccines / immunology*


  • Adjuvants, Immunologic
  • Allergens
  • Vaccines
  • Ovalbumin