Abstract
IgE, mast cells, basophils, and eosinophils are essential components of allergic inflammation. Antigen-specific IgE production, with subsequent fixation of IgE to FcepsilonRI receptors on mast cells and basophils, is central to the initiation and propagation of immediate hypersensitivity reactions. Mast cells, basophils, and eosinophils are central effector cells in allergic inflammation, as well as in innate and adaptive immunity. This review highlights what is known about these components and their roles in disease pathogenesis.
Copyright 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Intramural
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Review
MeSH terms
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Animals
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Antibodies, Anti-Idiotypic
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Antibodies, Monoclonal / therapeutic use
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Antibodies, Monoclonal, Humanized
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Basophils / immunology*
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Basophils / metabolism*
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Basophils / pathology
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Biomarkers / metabolism
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Cell Degranulation
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Cell Differentiation
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Cell Movement
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Cytokines / metabolism
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Eosinophils / immunology*
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Eosinophils / metabolism*
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Eosinophils / pathology
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Humans
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Hypersensitivity, Immediate / blood
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Hypersensitivity, Immediate / diagnosis
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Hypersensitivity, Immediate / immunology*
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Hypersensitivity, Immediate / therapy
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Immunoglobulin E / immunology
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Immunoglobulin E / metabolism*
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Mast Cells / immunology*
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Mast Cells / metabolism*
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Mast Cells / pathology
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Omalizumab
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Receptors, IgE / immunology
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Tryptases / blood
Substances
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Antibodies, Anti-Idiotypic
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Antibodies, Monoclonal
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Antibodies, Monoclonal, Humanized
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Biomarkers
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Cytokines
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Receptors, IgE
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Omalizumab
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Immunoglobulin E
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Tryptases