Evaluation of a 4-aminopiperidine replacement in several series of CCR5 antagonists

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1830-3. doi: 10.1016/j.bmcl.2010.02.004. Epub 2010 Feb 6.


The bicyclic 5-amino-3-azabicyclo[3.3.0]octanes were shown to be effective replacements for the conformationally restricted 4-aminopiperidine ring found in several series of CCR5 antagonists.

MeSH terms

  • CCR5 Receptor Antagonists*
  • Drug Evaluation, Preclinical*
  • Models, Molecular
  • Piperidines / chemistry*


  • 4-aminopiperidine
  • CCR5 Receptor Antagonists
  • Piperidines