Committee Opinion No. 455: Magnesium sulfate before anticipated preterm birth for neuroprotection

Obstet Gynecol. 2010 Mar;115(3):669-671. doi: 10.1097/AOG.0b013e3181d4ffa5.


Numerous large clinical studies have evaluated the evidence regarding magnesium sulfate, neuroprotection, and preterm births. The Committee on Obstetric Practice and the Society for Maternal-Fetal Medicine recognize that none of the individual studies found a benefit with regard to their primary outcome. However, the available evidence suggests that magnesium sulfate given before anticipated early preterm birth reduces the risk of cerebral palsy in surviving infants. Physicians electing to use magnesium sulfate for fetal neuroprotection should develop specific guidelines regarding inclusion criteria, treatment regimens, concurrent tocolysis, and monitoring in accordance with one of the larger trials.

MeSH terms

  • Cerebral Palsy / prevention & control*
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Magnesium Sulfate / therapeutic use*
  • Neuroprotective Agents / therapeutic use*
  • Obstetric Labor, Premature / drug therapy*
  • Pregnancy
  • Premature Birth
  • Tocolytic Agents / therapeutic use


  • Neuroprotective Agents
  • Tocolytic Agents
  • Magnesium Sulfate