T-helper 1, T-helper 2, and T-regulatory cytokines gene polymorphisms in irritable bowel syndrome

Inflammation. 2010 Oct;33(5):281-6. doi: 10.1007/s10753-010-9183-6.

Abstract

Inflammation and mucosal immune system activation have an important role in irritable bowel syndrome (IBS), whereas genetic factors can control some immunological mediators. In this study, a number of polymorphic genes coding for T-helper 1, T-helper 2, and T-regulatory cytokines were genotyped in 71 patients with IBS, and the results were compared with controls. IL-4 CC genotype at position -590, IL-4 TT genotype at position -33, and IL-10 GA genotype at position -1082 were significantly overrepresented in the patients with IBS in comparison with controls (P < 0.001). The frequencies of the following haplotypes in the patient group were significantly higher than in the control group: IL-2 (-330, +160) GT haplotype (P = 0.002), IL-4 (-1098, -590, -33) TCC haplotype (P < 0.001), and TCT haplotype (P < 0.001). While production of cytokines could be affected by genetic polymorphisms within coding and promoter regions of cytokine genes, IL-4 and IL-10 gene polymorphisms could affect individual susceptibility to IBS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Chi-Square Distribution
  • Cytokines / genetics*
  • Cytokines / metabolism
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Haplotypes
  • Humans
  • Interleukin-10 / genetics
  • Interleukin-2 / genetics
  • Interleukin-4 / genetics
  • Iran
  • Irritable Bowel Syndrome / genetics
  • Irritable Bowel Syndrome / immunology
  • Male
  • Middle Aged
  • Odds Ratio
  • Phenotype
  • Polymorphism, Genetic*
  • Risk Assessment
  • Risk Factors
  • T-Lymphocytes, Regulatory / immunology*
  • Th1 Cells / immunology*
  • Th2 Cells / immunology*

Substances

  • Cytokines
  • IL10 protein, human
  • IL2 protein, human
  • IL4 protein, human
  • Interleukin-2
  • Interleukin-10
  • Interleukin-4