Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2010 Apr;64(2):219-22.
doi: 10.1007/s11418-010-0395-8. Epub 2010 Feb 23.

Inhibitory Effects of Devil's Claw (Secondary Root of Harpagophytum Procumbens) Extract and Harpagoside on Cytokine Production in Mouse Macrophages

Affiliations
Comparative Study

Inhibitory Effects of Devil's Claw (Secondary Root of Harpagophytum Procumbens) Extract and Harpagoside on Cytokine Production in Mouse Macrophages

Kazunori Inaba et al. J Nat Med. .

Abstract

Successive oral administration (50 mg/kg) of a 50% ethanolic extract (HP-ext) of devil's claw, the secondary root of Harpagophytum procumbens, showed a significant anti-inflammatory effect in the rat adjuvant-induced chronic arthritis model. HP-ext dose-dependently suppressed the lipopolysaccharide (LPS)-induced production of inflammatory cytokines [interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)] in mouse macrophage cells (RAW 264.7). Harpagoside, a major iridoid glycoside present in devil's claw, was found to be one of the active agents in HP-ext and inhibited the production of IL-1beta, IL-6, and TNF-alpha by RAW 264.7.

Similar articles

See all similar articles

Cited by 8 articles

See all "Cited by" articles

References

    1. J Pharmacol Exp Ther. 1979 Oct;211(1):20-5 - PubMed
    1. J Ethnopharmacol. 2004 Apr;91(2-3):325-30 - PubMed
    1. J Ethnopharmacol. 2006 Mar 8;104(1-2):149-55 - PubMed
    1. J Pharmacol Sci. 2003 Nov;93(3):367-71 - PubMed
    1. Planta Med. 1992 Apr;58(2):117-23 - PubMed

Publication types

MeSH terms

LinkOut - more resources

Feedback