Lin28: A microRNA regulator with a macro role

Cell. 2010 Feb 19;140(4):445-9. doi: 10.1016/j.cell.2010.02.007.


Lin28, a highly conserved RNA-binding protein, has emerged as a modulator of the processing of the let-7 microRNA. This role for Lin28 has important implications for our mechanistic understanding of pluripotency, the timing of development, and oncogenesis.

MeSH terms

  • Animals
  • Humans
  • Induced Pluripotent Stem Cells / metabolism
  • MicroRNAs / genetics*
  • Neoplasms / metabolism
  • Protein Processing, Post-Translational*
  • RNA-Binding Proteins / genetics*
  • Stem Cells / metabolism


  • Lin28A protein, human
  • MicroRNAs
  • RNA-Binding Proteins
  • mirnlet7 microRNA, human