Lymphangiogenesis: Molecular mechanisms and future promise

Cell. 2010 Feb 19;140(4):460-76. doi: 10.1016/j.cell.2010.01.045.


The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of pathological processes including tissue inflammation and tumor dissemination but is insufficient in patients suffering from lymphedema, a debilitating condition characterized by chronic tissue edema and impaired immunity. The recent explosion of knowledge on the molecular mechanisms governing lymphangiogenesis provides new possibilities to treat these diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Endothelial Cells / physiology
  • Humans
  • Inflammation / physiopathology
  • Lymphangiogenesis* / drug effects
  • Lymphatic Vessels / physiology
  • Lymphatic Vessels / physiopathology
  • Neoplasms / physiopathology