DNA repair: how MutM finds the needle in a haystack

Curr Biol. 2010 Feb 23;20(4):R145-7. doi: 10.1016/j.cub.2009.12.046.

Abstract

High-resolution crystal structures of DNA complexes with the bacterial MutM protein show how the enzyme feels its way around the double helix in search of an oxidized guanine before flipping it out into its active site and excising it.

Publication types

  • Review

MeSH terms

  • DNA / metabolism*
  • DNA Repair / physiology*
  • DNA-Formamidopyrimidine Glycosylase / metabolism*
  • Escherichia coli Proteins / metabolism*
  • Macromolecular Substances / metabolism*
  • Models, Genetic*
  • Nucleic Acid Conformation

Substances

  • Escherichia coli Proteins
  • Macromolecular Substances
  • DNA
  • DNA-Formamidopyrimidine Glycosylase
  • DNA-formamidopyrimidine glycosylase, E coli