XLMR genes: update 1990

Am J Med Genet. 1991 Feb-Mar;38(2-3):186-9. doi: 10.1002/ajmg.1320380204.


We have identified 39 X-linked conditions in which mental retardation seems to be the primary characteristic, although pathogenesis is unknown. These conditions can be subdivided into syndromal and non-syndromal, depending on the existence of a recognizable pattern of minor anomalies and/or malformations, or lack thereof. Seventeen genes have been regionally mapped onto the X chromosome. However, in 14 instances the data were derived from a single family and most lod scores were less than 3.0.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping
  • Congenital Abnormalities / genetics
  • Female
  • Genetic Markers
  • Humans
  • Intellectual Disability / classification
  • Intellectual Disability / genetics*
  • Male
  • X Chromosome*


  • Genetic Markers