Determination of methylamines and trimethylamine-N-oxide in particulate matter by non-suppressed ion chromatography

J Chromatogr A. 2010 Mar 26;1217(13):2070-3. doi: 10.1016/j.chroma.2010.01.066. Epub 2010 Jan 29.


An ion chromatography method with non-suppressed conductivity detection was developed for the simultaneous determination of methylamines (methylamine, dimethylamine, trimethylamine) and trimethylamine-N-oxide in particulate matter air samples. The analytes were well separated by means of cation-exchange chromatography using a 3 mM nitric acid/3.5% acetonitrile (v/v) eluent solution and a Metrosep C 2 250 (250 mm x 4 mm i.d.) separation column. The effects of the different chromatographic parameters on the separation were also investigated. Detection limits of methylamine, dimethylamine, trimethylamine, and trimethylamine-N-oxide were 43, 46, 76 and 72 microg/L, respectively. The relative standard deviations of the retention times were between 0.42% and 1.14% while the recoveries were between 78.8% and 88.3%. The method is suitable for determining if methylamines and trimethylamine-N-oxide are a significant component of organic nitrogen aerosol in areas with high concentration of these species.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Air Pollutants / analysis*
  • Chromatography, Ion Exchange / methods*
  • Limit of Detection
  • Methylamines / analysis*
  • Oxides / analysis*
  • Particulate Matter / analysis*


  • Air Pollutants
  • Methylamines
  • Oxides
  • Particulate Matter