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. 2010 Apr;17(4):582-7.
doi: 10.1128/CVI.00379-09. Epub 2010 Feb 24.

Cytokines Across the Night in Chronic Fatigue Syndrome With and Without Fibromyalgia

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Free PMC article

Cytokines Across the Night in Chronic Fatigue Syndrome With and Without Fibromyalgia

Toru Nakamura et al. Clin Vaccine Immunol. .
Free PMC article

Abstract

The symptoms of chronic fatigue syndrome (CFS) are consistent with cytokine dysregulation. This has led to the hypothesis of immune dysregulation as the cause of this illness. To further test this hypothesis, we did repeated blood sampling for cytokines while patients and matched healthy controls slept in the sleep lab. Because no one method for assaying cytokines is acknowledged to be better than another, we assayed for protein in serum, message in peripheral blood lymphocytes (PBLs), and function in resting and stimulated PBLs. We found no evidence of proinflammatory cytokine upregulation. Instead, in line with some of our earlier studies, we did find some evidence to support a role for an increase in interleukin-10, an anti-inflammatory cytokine. Although the changes were small, they may contribute to the common complaint in CFS patients of disrupted sleep.

Figures

FIG. 1.
FIG. 1.
Group-averaged IL-10 levels (in pg/ml) from the Luminex assay for control, CFS with FM, and CFS without FM groups. The error bars indicate standard errors of means. *, significant difference from control; †, significant difference between CFS with FM and CFS without FM. Note that the statistical tests were conducted with logarithmic-transformed data.

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