Asphorodin, a potent lipoxygenase inhibitory triterpene diglycoside from Asphodelus tenuifolius

Muhammad Safder; Muhammad Imran; Rashad Mehmood; Abdul Malik; Nighat Afza; Lubna Iqbal; Mehreen Latif

doi:10.1080/10286020903214197

Asphorodin, a potent lipoxygenase inhibitory triterpene diglycoside from Asphodelus tenuifolius

J Asian Nat Prod Res. 2009 Nov;11(11):945-50. doi: 10.1080/10286020903214197.

Authors

Muhammad Safder¹, Muhammad Imran, Rashad Mehmood, Abdul Malik, Nighat Afza, Lubna Iqbal, Mehreen Latif

Affiliation

¹ International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.

PMID: 20183258
DOI: 10.1080/10286020903214197

Abstract

Asphorodin (1), a new diglycoside, has been isolated from the ethyl acetate-soluble fraction of Asphodelus tenuifolius. It showed significant inhibitory activity against the enzyme lipoxygenase in a concentration-dependent manner. The Lineweaver-Burk and Dixon plots indicated that the nature of inhibition was non-competitive.

MeSH terms

Dose-Response Relationship, Drug
Glycosides / chemistry
Glycosides / isolation & purification*
Glycosides / pharmacology*
Liliaceae / chemistry*
Lipoxygenase Inhibitors / chemistry
Lipoxygenase Inhibitors / isolation & purification*
Lipoxygenase Inhibitors / pharmacology*
Molecular Structure
Pakistan
Triterpenes / chemistry
Triterpenes / isolation & purification*
Triterpenes / pharmacology*

Substances

Glycosides
Lipoxygenase Inhibitors
Triterpenes
asphorodin