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Review
. 2010 Apr:125 Suppl 1:S70-3.
doi: 10.1016/j.thromres.2010.01.042. Epub 2010 Feb 24.

Cellular sources of tissue factor in endotoxemia and sepsis

Rafal Pawlinski  1 , Nigel Mackman
Affiliations
Free PMC article
Review

Cellular sources of tissue factor in endotoxemia and sepsis

Rafal Pawlinski et al. Thromb Res. 2010 Apr.
Free PMC article

Abstract

Sepsis is a systemic host response to infection by pathogenic microorganisms. Activation of the coagulation cascade during endotoxemia and sepsis leads to disseminated intravascular coagulation. This review focuses on tissue factor expression by hematopoietic and non-hematopoietic cells and its contribution to the activation of coagulation during endotoxemia and sepsis.

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Conflict of interest statement

Conflict of interest

The authors state that they have no conflict of interest.

Figures

Figure 1
Figure 1. Cellular sources of TF
Activated monocytes and parenchymal cells are two major sources of TF that contribute to activation of coagulation and DIC during sepsis and endotoxemia. In addition, activated monocytes are the main source of TF-positive microparticles which bind to endothelial cells, platelets and granulocytes. The contribution of TF-positive microparticles to the development of DIC has not been determined.
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