Overexpression of glucocorticoid receptor-beta in severe allergic rhinitis

Auris Nasus Larynx. 2010 Oct;37(5):584-8. doi: 10.1016/j.anl.2009.12.002. Epub 2010 Feb 24.


Objective: To clarify the role of glucocorticoid receptor-beta in resistance to glucocorticoid therapy for allergic rhinitis, we studied 37 tissue samples from 20 patients with severe allergic rhinitis, and samples from age-matched controls.

Methods: Patients were treated with intranasal fluticasone for 6 months and inferior turbinectomy was performed for patients with poor response to glucocorticoid treatment. The expression of glucocorticoid receptor-alpha (GR-alpha), glucocorticoid receptor-beta (GR-beta), and nuclear factor-kappaB (NF-kappaB) in nasal mucosa was studied immunohistochemically.

Results: GR-alpha and NF-kappaB were expressed to a similar extent in patients and controls, but GR-beta was expressed significantly more in patients, resulting in an increased GR-beta/GR-alpha ratio.

Conclusion: Our findings suggest that GR-beta plays an important role in resistance to glucocorticoid therapy for allergic rhinitis, and its expression might be used as an additional parameter indicating steroid resistance in allergic rhinitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Intranasal
  • Adult
  • Androstadienes / therapeutic use*
  • Anti-Inflammatory Agents / therapeutic use*
  • Drug Resistance
  • Female
  • Fluticasone
  • Humans
  • Male
  • Microscopy, Fluorescence
  • NF-kappa B / analysis*
  • NF-kappa B / drug effects
  • Nasal Mucosa / drug effects
  • Nasal Mucosa / immunology
  • Nasal Mucosa / pathology
  • Receptors, Glucocorticoid / analysis*
  • Receptors, Glucocorticoid / drug effects
  • Reference Values
  • Rhinitis, Allergic, Perennial / drug therapy
  • Rhinitis, Allergic, Perennial / immunology
  • Rhinitis, Allergic, Perennial / pathology*
  • Young Adult


  • Androstadienes
  • Anti-Inflammatory Agents
  • NF-kappa B
  • Receptors, Glucocorticoid
  • glucocorticoid receptor alpha
  • glucocorticoid receptor beta
  • Fluticasone