Critical pneumonia complicating early-stage pregnancy

Anesth Analg. 2010 Mar 1;110(3):852-4. doi: 10.1213/ANE.0b013e3181cc55a5.

Abstract

We present a case of community-acquired methicillin-resistant Staphylococcus aureus necrotizing pneumonia, Panton-Valentine leukocidin positive, in a woman at 14 weeks of pregnancy. To our knowledge, this is the first case reporting this critical lung infection occurring during an early phase of pregnancy. This case study alerts physicians to the increasing worldwide spread of these uncommon yet virulent and potentially lethal infections. In our patient, antibiotic therapy with linezolid plus rifampin started at 14 weeks of pregnancy had a successful outcome without inducing toxicity or teratogenesis in the fetus.

Publication types

  • Case Reports

MeSH terms

  • Acetamides / therapeutic use
  • Anti-Bacterial Agents / therapeutic use
  • Bacterial Toxins / metabolism
  • Drug Therapy, Combination
  • Exotoxins / metabolism
  • Female
  • Humans
  • Leukocidins / metabolism
  • Linezolid
  • Lung / diagnostic imaging
  • Lung / drug effects
  • Lung / microbiology*
  • Methicillin-Resistant Staphylococcus aureus / isolation & purification*
  • Methicillin-Resistant Staphylococcus aureus / metabolism
  • Necrosis
  • Oxazolidinones / therapeutic use
  • Pneumonia, Staphylococcal / diagnostic imaging
  • Pneumonia, Staphylococcal / drug therapy
  • Pneumonia, Staphylococcal / microbiology*
  • Pregnancy
  • Pregnancy Complications, Infectious / diagnostic imaging
  • Pregnancy Complications, Infectious / drug therapy
  • Pregnancy Complications, Infectious / microbiology*
  • Pregnancy Trimester, First
  • Radiography
  • Rifampin / therapeutic use
  • Treatment Outcome
  • Young Adult

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Bacterial Toxins
  • Exotoxins
  • Leukocidins
  • Oxazolidinones
  • Panton-Valentine leukocidin
  • Linezolid
  • Rifampin