[Role of beta-glucan in the treatment of recurrent candidiasis and HPV-correlated lesions and reparative process of epidermis]

Minerva Ginecol. 2010 Feb;62(1):1-5.
[Article in Italian]


Aim: The aim of the study was to examine the effects of beta-glucan treatment in women with recurrent vulvar candidiasis or previously treated with diathermocoagulation (DTC) for vulvar lesions caused by human papillomavirus (HPV) infection.

Methods: From January to March 2008, 23 women with a history of recurrent candidiasis and 209 women who underwent to DTC for HPV-correlated vulvar lesions were recruited at the Department of Obstetrics and Gynaeco-logy of San Camillo-Forlanini Hospital of Rome. The two groups were treated with two cycles of a daily topical application of beta-glucan for 15 consecutive days with a suspension of 20 days. The effects of beta-glucan were analyzed at the 1st and the 3rd month from the start of the therapy.

Results: A total of 209 women, 21 with recurrent candidiasis and 188 who underwent to DTC for HPV-correlated lesions, completed the study. After the first month of treatment we not found any evidence of disease in both groups; otherwise we observed, a month after the term of the therapy, 5% and 3% of recurrence of candidiasis or lesions secondary to HPV infection, respectively, even if with low grade.

Conclusions: Our results demonstrate the efficacy of beta-glucan treatment for recurrent candidiasis, HPV-correlated lesions and in the reparative process of epidermis.

Publication types

  • Clinical Trial
  • English Abstract

MeSH terms

  • Adjuvants, Immunologic / administration & dosage
  • Adjuvants, Immunologic / pharmacology
  • Adjuvants, Immunologic / therapeutic use*
  • Administration, Topical
  • Adult
  • Alphapapillomavirus*
  • Candidiasis, Vulvovaginal / drug therapy*
  • Candidiasis, Vulvovaginal / prevention & control
  • Condylomata Acuminata / drug therapy*
  • Epidermis / drug effects*
  • Epidermis / physiology
  • Female
  • Humans
  • Recurrence
  • Regeneration / drug effects
  • Signal Transduction / drug effects
  • Vulvar Diseases / drug therapy*
  • Vulvar Diseases / virology
  • Young Adult
  • beta-Glucans / administration & dosage
  • beta-Glucans / pharmacology
  • beta-Glucans / therapeutic use*


  • Adjuvants, Immunologic
  • beta-Glucans