Calpinactam, a new anti-mycobacterial agent, produced by Mortierella alpina FKI-4905
- PMID: 20186169
- DOI: 10.1038/ja.2010.14
Calpinactam, a new anti-mycobacterial agent, produced by Mortierella alpina FKI-4905
Abstract
Calpinactam, a new anti-mycobacterial agent, was isolated from the culture broth of a fungal strain Mortierella alpina FKI-4905 by solvent extraction, octadecyl silane column chromatography and preparative HPLC. Calpinactam was active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibited the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 microg ml(-1), respectively.
Similar articles
-
Structure and total synthesis of fungal calpinactam, a new antimycobacterial agent.Org Lett. 2010 Feb 5;12(3):432-5. doi: 10.1021/ol902553z. Org Lett. 2010. PMID: 20030344
-
Synthesis and antimycobacterial activity of calpinactam derivatives.Bioorg Med Chem Lett. 2012 Dec 15;22(24):7739-41. doi: 10.1016/j.bmcl.2012.09.069. Epub 2012 Oct 12. Bioorg Med Chem Lett. 2012. PMID: 23116887
-
Lariatins, novel anti-mycobacterial peptides with a lasso structure, produced by Rhodococcus jostii K01-B0171.J Antibiot (Tokyo). 2007 Jun;60(6):357-63. doi: 10.1038/ja.2007.48. J Antibiot (Tokyo). 2007. PMID: 17617692
-
Improved production of various polyunsaturated fatty acids through filamentous fungus Mortierella alpina breeding.Appl Microbiol Biotechnol. 2009 Aug;84(1):1-10. doi: 10.1007/s00253-009-2076-7. Epub 2009 Jun 30. Appl Microbiol Biotechnol. 2009. PMID: 19565237 Review.
-
[Progress in production of arachidonic acid by Mortierella alpina and genetic modification].Sheng Wu Gong Cheng Xue Bao. 2010 Sep;26(9):1232-8. Sheng Wu Gong Cheng Xue Bao. 2010. PMID: 21141113 Review. Chinese.
Cited by
-
Regulation of the Leucine Metabolism in Mortierella alpina.J Fungi (Basel). 2022 Feb 18;8(2):196. doi: 10.3390/jof8020196. J Fungi (Basel). 2022. PMID: 35205950 Free PMC article.
-
Discovery of new hazimycin congeners from Kitasatospora sp. P07101.Acta Pharm Sin B. 2015 Nov;5(6):564-8. doi: 10.1016/j.apsb.2015.07.010. Epub 2015 Nov 2. Acta Pharm Sin B. 2015. PMID: 26713271 Free PMC article.
-
Mycobacterium tuberculosis cell-wall and antimicrobial peptides: a mission impossible?Front Immunol. 2023 May 17;14:1194923. doi: 10.3389/fimmu.2023.1194923. eCollection 2023. Front Immunol. 2023. PMID: 37266428 Free PMC article. Review.
-
Bacterial-Like Nonribosomal Peptide Synthetases Produce Cyclopeptides in the Zygomycetous Fungus Mortierella alpina.Appl Environ Microbiol. 2021 Jan 15;87(3):e02051-20. doi: 10.1128/AEM.02051-20. Print 2021 Jan 15. Appl Environ Microbiol. 2021. PMID: 33158886 Free PMC article.
-
Exploring the potential of endophytes from medicinal plants as sources of antimycobacterial compounds.Microbiol Res. 2014 Jul-Aug;169(7-8):483-95. doi: 10.1016/j.micres.2013.12.009. Epub 2014 Jan 15. Microbiol Res. 2014. PMID: 24582778 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
