Cushing's syndrome and adrenal insufficiency after intradermal triamcinolone acetonide for keloid scars

Eur J Pediatr. 2010 Sep;169(9):1147-9. doi: 10.1007/s00431-010-1165-z. Epub 2010 Feb 26.


A 6-year-old girl was admitted to our hospital for excessive weight gain. On presentation, she had a typical Cushingoid appearance and hypertension. Laboratory analysis was indicative for an exogenous glucocorticoid source, showing values that were low for serum cortisol and adrenocorticotropin and for 24-h urinary glucocorticoid (metabolite) excretion. Five and 2 months before presentation, she was treated with intradermal triamcinolone acetonide for keloid scars. Recovery of intrinsic cortisol production occurred 12 months after the last steroid dose. Intradermal triamcinolone acetonide for keloid scars in children should be used with care taking into account the here reported complication.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Insufficiency / blood
  • Adrenal Insufficiency / chemically induced*
  • Adrenal Insufficiency / physiopathology
  • Adrenocorticotropic Hormone / blood
  • Child
  • Cushing Syndrome / blood
  • Cushing Syndrome / chemically induced*
  • Cushing Syndrome / physiopathology
  • Female
  • Glucocorticoids / administration & dosage
  • Glucocorticoids / adverse effects*
  • Humans
  • Hydrocortisone / blood
  • Hypertension / chemically induced
  • Injections, Intradermal
  • Keloid / drug therapy*
  • Triamcinolone Acetonide / administration & dosage
  • Triamcinolone Acetonide / adverse effects*


  • Glucocorticoids
  • Adrenocorticotropic Hormone
  • Triamcinolone Acetonide
  • Hydrocortisone