Guggullipid derivatives: synthesis and applications

Chem Phys Lipids. 2010 May;163(4-5):362-6. doi: 10.1016/j.chemphyslip.2010.02.004. Epub 2010 Feb 25.


Two guggullipid derivatives, Z-guggulsulfate [4,17(20)-pregnadiene-3-one-16beta-sulfate] sodium salt and Z-guggullaurate [4,17(20)-pregnadiene-3-one-16beta-laurate], have been synthesized and evaluated for liposomal drug delivery system. Its precursor, Z-guggulsterol [4,17(20)-pregnadiene-3-one-16beta-ol], is also synthesized in gram scale starting from guggulsterone using the novel combination of known reactions in fewer steps and with higher yield than previously reported synthesis. These new synthetic guggullipid derivatives were also used in the preparation of liposomes. This new class of lipid molecules will be a useful tool in the development of nanosomal or liposomal drug delivery system.

MeSH terms

  • Commiphora
  • Drug Carriers / chemistry*
  • Liposomes / chemistry*
  • Plant Extracts / analysis
  • Plant Extracts / chemical synthesis*
  • Plant Gums / analysis
  • Plant Gums / chemical synthesis*


  • Drug Carriers
  • Liposomes
  • Plant Extracts
  • Plant Gums
  • guggulu extract