Association analysis between polymorphism rs2373115 of gene GRB-associated binding protein 2 and Mongolian Alzheimer patients

Sirui Zhou; Huriletemuer; Jing Wang; Binbin Wang; Shigang Zhao; De Sheng Wang; Chunyu Zhang; Xu Ma

doi:10.1016/j.neulet.2010.02.047

Association analysis between polymorphism rs2373115 of gene GRB-associated binding protein 2 and Mongolian Alzheimer patients

Neurosci Lett. 2010 Aug 9;480(1):4-6. doi: 10.1016/j.neulet.2010.02.047. Epub 2010 Feb 25.

Authors

Sirui Zhou¹, Huriletemuer, Jing Wang, Binbin Wang, Shigang Zhao, De Sheng Wang, Chunyu Zhang, Xu Ma

Affiliation

¹ Graduate School, Peking Union Medical College, Beijing 100730, China.

PMID: 20188796
DOI: 10.1016/j.neulet.2010.02.047

Abstract

GRB-associated binding protein 2 (GAB2) may function as a risk factor of Alzheimer disease (AD) by affecting hyperphosphorylation of tau, causing neurofibrillary tangles. There had been genomewide analysis discovering polymorphism rs2373115 correlated with AD and in this study we performed an association analysis on this polymorphism in 107:100 Mongolian Alzheimer patients and controls in order to discover whether this correlation can be replicated in Chinese minority group. The results showed negative results, indicating GAB2 rs2373115 polymorphism was not a remarkable factor in developing Alzheimer disease among Mongolian.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Signal Transducing / genetics*
Aged
Alzheimer Disease / genetics*
Asian People*
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Male
Mongolia
Polymorphism, Genetic

Substances

Adaptor Proteins, Signal Transducing
GAB2 protein, human