A comprehensive analysis of parotid and salivary gland cancer: worse outcomes for male gender

J Surg Res. 2011 Nov;171(1):151-8. doi: 10.1016/j.jss.2009.11.721. Epub 2010 Feb 6.


Background: To determine the effects of patient demographics, socioeconomic status (SES) and clinical variables on outcomes for patients with salivary and parotid gland tumors.

Methods: Florida cancer registry and inpatient hospital data were queried for cancer of the salivary glands diagnosed between 1998-2002.

Results: A total of 1573 patients were identified. Women were diagnosed at a younger age (median age (years): women 60.8 versus men 64.3, P=0.003). Men were more often diagnosed with high grade tumors (65.1% versus 41.9% for women, P<0.001) and advanced disease stage (>stage III: 60.2 versus 49.4%, P<0.001), but underwent surgical extirpation and received radiation at equal rates compared with women. Overall 5-year survival rates was superior in women (67.4% versus 55.6%, P=0.001). By multivariate analysis, adjusted for patient comorbidities, age over 65 (HR 3.43 P=0.008), advanced disease stage (HR 8.05 P<0.001), and high tumor grade (HR 2.33, P<0.001) were independent predictors of worse prognosis. Improved outcomes were observed for female gender (HR 0.68, P=0.011). Tumors located in the parotid gland (HR 0.631 P=0.003) and receiving both surgical extirpation and radiation were predictors of improved survival.

Conclusion: Salivary gland tumors carry a worse prognosis than tumors of the parotid. Male patients have worse outcomes.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Distribution
  • Aged
  • Comorbidity
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Grading
  • Parotid Neoplasms / mortality
  • Parotid Neoplasms / pathology
  • Predictive Value of Tests
  • Prognosis
  • Risk Factors
  • Salivary Gland Neoplasms / mortality*
  • Salivary Gland Neoplasms / pathology*
  • Sex Distribution
  • Sublingual Gland Neoplasms / mortality
  • Sublingual Gland Neoplasms / pathology
  • Submandibular Gland Neoplasms / mortality
  • Submandibular Gland Neoplasms / pathology
  • Survival Analysis