Abstract
A series of thiourea derivatives of 4-azatricyclo[5.2.2.0(2,6)]undec-8-ene-3,5-dione were synthesized. The compounds were investigated for antibacterial activity, including Gram-positive cocci, Gram-negative rods, and antifungal activity. Compounds 1b, 2b, 4b showed significant inhibition against Gram-positive cocci. Research was carried out over 10 standard strains and 20 hospital strains. Synthesized compounds were evaluated for their cytotoxicity and anti-HIV-1 activity in MT-4 cells.
MeSH terms
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Anti-HIV Agents / chemical synthesis
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Anti-HIV Agents / pharmacology
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Anti-Infective Agents / chemical synthesis*
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Anti-Infective Agents / pharmacology*
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology
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Antiviral Agents / chemical synthesis
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Antiviral Agents / pharmacology
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Bacteria / drug effects
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Cell Survival / drug effects
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Chromatography, High Pressure Liquid
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Chromatography, Thin Layer
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Culture Media
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Drug Screening Assays, Antitumor
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Fungi / drug effects
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HIV-1 / drug effects
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Heterocyclic Compounds, 3-Ring / chemical synthesis*
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Heterocyclic Compounds, 3-Ring / pharmacology*
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Humans
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Structure-Activity Relationship
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Thiourea / analogs & derivatives*
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Thiourea / chemical synthesis*
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Thiourea / pharmacology
Substances
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Anti-HIV Agents
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Anti-Infective Agents
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Antineoplastic Agents
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Antiviral Agents
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Culture Media
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Heterocyclic Compounds, 3-Ring
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Indicators and Reagents
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Thiourea