Bimodal MR-PET agent for quantitative pH imaging

Angew Chem Int Ed Engl. 2010 Mar 22;49(13):2382-4. doi: 10.1002/anie.201000075.


Activatable or “smart” magnetic resonance contrast agents have relaxivities that depend on environmental factors such as pH or enzymatic activity, but the MR signal depends on relaxivity and agent concentration – two unknowns. A bimodal approach, incorporating a positron emitter, solves this problem. Simultaneous positron emission tomography (PET) and MR imaging with the biomodal, pH-responsive MR-PET agent GdDOTA-4AMP-F allows direct determination of both concentration (PET) and T1 (MRI), and hence pH.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Contrast Media / chemistry*
  • Fluorine / chemistry
  • Heterocyclic Compounds, 1-Ring / chemistry
  • Hydrogen-Ion Concentration
  • Magnetic Resonance Imaging*
  • Molecular Structure
  • Organometallic Compounds / chemistry
  • Positron-Emission Tomography*


  • Contrast Media
  • Gd-DOTA-4amP
  • Heterocyclic Compounds, 1-Ring
  • Organometallic Compounds
  • Fluorine