Ultrasonographic features of papillary thyroid carcinoma in patients with Graves' disease

Korean J Intern Med. 2010 Mar;25(1):71-6. doi: 10.3904/kjim.2010.25.1.71. Epub 2010 Feb 26.


Background/aims: To characterize ultrasonographic findings in papillary thyroid carcinoma (PTC) combined with Graves' disease.

Methods: Medical records and ultrasonographic findings of 1,013 patients with Graves' disease and 3,380 patients without Graves' disease were analyzed retrospectively. A diagnosis of PTC was based on a pathologic examination.

Results: The frequency of hypoechogenicity was lower in patients with PTC and Graves' disease than in patients with PTC alone (p < 0.05). The frequency of perinodular blood flow in patients with PTC and Graves' disease was significantly higher than in those with PTC alone (p < 0.05). PTC combined with Graves' disease was characterized by more ill-defined borders and less frequency of overall calcification, punctate calcification, and heterogeneous echogenicity, although the difference was not statistically significant.

Conclusions: Our results suggest that patients with Graves' disease more frequently have atypical PTC findings on ultrasonography.

Keywords: Graves disease; Thyroid neoplasms; Ultrasonography.

MeSH terms

  • Adult
  • Carcinoma, Papillary / diagnostic imaging*
  • Female
  • Graves Disease / diagnostic imaging*
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Thyroid Gland / diagnostic imaging*
  • Thyroid Neoplasms / diagnostic imaging*
  • Ultrasonography / methods*