Estimating prevalence of coronary heart disease for small areas using collateral indicators of morbidity

Int J Environ Res Public Health. 2010 Jan;7(1):164-77. doi: 10.3390/ijerph7010164. Epub 2010 Jan 18.


Different indicators of morbidity for chronic disease may not necessarily be available at a disaggregated spatial scale (e.g., for small areas with populations under 10 thousand). Instead certain indicators may only be available at a more highly aggregated spatial scale; for example, deaths may be recorded for small areas, but disease prevalence only at a considerably higher spatial scale. Nevertheless prevalence estimates at small area level are important for assessing health need. An instance is provided by England where deaths and hospital admissions for coronary heart disease are available for small areas known as wards, but prevalence is only available for relatively large health authority areas. To estimate CHD prevalence at small area level in such a situation, a shared random effect method is proposed that pools information regarding spatial morbidity contrasts over different indicators (deaths, hospitalizations, prevalence). The shared random effect approach also incorporates differences between small areas in known risk factors (e.g., income, ethnic structure). A Poisson-multinomial equivalence may be used to ensure small area prevalence estimates sum to the known higher area total. An illustration is provided by data for London using hospital admissions and CHD deaths at ward level, together with CHD prevalence totals for considerably larger local health authority areas. The shared random effect involved a spatially correlated common factor, that accounts for clustering in latent risk factors, and also provides a summary measure of small area CHD morbidity.

Keywords: Bayesian; Prevalence; common factor; coronary heart disease; spatial correlation.

MeSH terms

  • Bayes Theorem
  • Coronary Disease / epidemiology*
  • Humans
  • London / epidemiology
  • Models, Statistical*
  • Monte Carlo Method
  • Prevalence