[HIV-associated neuropathies]

Nervenarzt. 2010 Apr;81(4):409-17. doi: 10.1007/s00115-010-2931-x.
[Article in German]


Human immunodeficiency virus (HIV)-associated polyneuropathy has become the most common neurological complication of HIV infection and is one of the main risk factors for development of a neuropathy worldwide. Therefore HIV should always be considered as an underlying cause in patients with neuropathy. Many types of peripheral neuropathies are seen in HIV infection depending on the stage of infection. The inflammatory demyelinating neuropathies both acute (Guillain-Barré syndrome, GBS) and chronic (chronic inflammatory demyelinating neuropathy, CIDP) occur mainly at the time of seroconversion or early in the course of the disease while syndromes associated with opportunistic infections like CMV (i.e. polyradiculoneuropathy) occur in the late phase of HIV infection and are related to the loss of immune function. Distal symmetrical polyneuropathy (DSP) is the most common neuropathy in HIV-infected patients. We review the clinical manifestations, epidemiology, clinical diagnostics, pathophysiology and management strategies for HIV-associated polyneuropathies.

Publication types

  • English Abstract
  • Review

MeSH terms

  • AIDS-Related Opportunistic Infections / diagnosis
  • AIDS-Related Opportunistic Infections / epidemiology
  • AIDS-Related Opportunistic Infections / therapy
  • Cross-Sectional Studies
  • Cytomegalovirus Infections / diagnosis
  • Cytomegalovirus Infections / epidemiology
  • Cytomegalovirus Infections / therapy
  • Guillain-Barre Syndrome / diagnosis
  • Guillain-Barre Syndrome / epidemiology
  • Guillain-Barre Syndrome / therapy
  • HIV Infections / diagnosis*
  • HIV Infections / epidemiology
  • HIV Infections / therapy
  • HIV Seropositivity / diagnosis
  • Humans
  • Polyneuropathies / diagnosis*
  • Polyneuropathies / epidemiology
  • Polyneuropathies / therapy
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / diagnosis
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / epidemiology
  • Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / therapy