Persistent symptoms in mild to moderate traumatic brain injury associated with executive dysfunction

J Clin Exp Neuropsychol. 2010 Aug;32(7):767-74. doi: 10.1080/13803390903521000. Epub 2010 Mar 1.


In order to improve detection of subtle cognitive dysfunction and to shed light on the etiology of persistent symptoms after mild-to-moderate traumatic brain injury (TBI), we employed an experimental executive reaction time (RT) test, standardized neuropsychological tests, and diffusion tensor imaging (DTI). The Executive RT-Test, an Executive Composite Score from standardized neuropsychological tests, and DTI-indices in the midbrain differentiated between patients with persistent symptoms from those fully recovered after mild-to-moderate TBI. We suggest that persistent symptoms in mild-to-moderate TBI may reflect disrupted fronto-striatal network involved in executive functioning, and the Executive RT-Test provides an objective and novel method to detect it.

MeSH terms

  • Adult
  • Brain / pathology
  • Brain Injuries / pathology
  • Brain Injuries / psychology*
  • Cognition / physiology
  • Depression / etiology
  • Depression / psychology
  • Diffusion Magnetic Resonance Imaging
  • Executive Function / physiology*
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Male
  • Middle Aged
  • Mood Disorders / etiology
  • Mood Disorders / psychology
  • Neuropsychological Tests
  • Psychiatric Status Rating Scales
  • Reaction Time / physiology
  • Severity of Illness Index
  • Surveys and Questionnaires
  • Young Adult