Signaling by ROS drives inflammasome activation

Eur J Immunol. 2010 Mar;40(3):616-9. doi: 10.1002/eji.200940168.


Inflammasomes are innate immune signaling pathways that sense pathogens and injury to direct the proteolytic maturation of inflammatory cytokines such as IL-1beta and IL-18. Among inflammasomes, the NLRP3/NALP3 inflammasome is the most studied. However, little is known on the molecular mechanisms that mediate its assembly and activation. Recent findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP3/NALP3 inflammasome activation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carrier Proteins / immunology
  • Humans
  • Inflammation / immunology*
  • Multiprotein Complexes / immunology*
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Oxidative Stress / immunology
  • Reactive Oxygen Species / immunology*
  • Signal Transduction / immunology*


  • Carrier Proteins
  • Multiprotein Complexes
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRP3 protein, human
  • Reactive Oxygen Species