Critical functions of priming and lysosomal damage for NLRP3 activation

Eur J Immunol. 2010 Mar;40(3):620-3. doi: 10.1002/eji.200940185.


Inflammasomes are cytosolic multi-protein complexes that form in response to infectious or injurious challenges. Inflammasomes control the activity of caspase-1, which is essential for the maturation and release of IL-1beta family cytokines. The NLRP1, IPAF and AIM2 inflammasomes recognize specific substances, while the NLRP3 inflammasome responds to many structurally and chemically diverse triggers. Here, we discuss the critical roles of priming and lysosomal damage in NLRP3 inflammasome activation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carrier Proteins / immunology*
  • Humans
  • Inflammation / immunology*
  • Lysosomes / immunology*
  • Multiprotein Complexes / immunology*
  • NLR Family, Pyrin Domain-Containing 3 Protein


  • Carrier Proteins
  • Multiprotein Complexes
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRP3 protein, human