Toxicokinetic interaction between quetiapine and antiretroviral therapy following quetiapine overdose

Drug Metab Lett. 2010 Jan;4(1):7-8. doi: 10.2174/187231210790980426.

Abstract

A 47-year-old woman ingested an overdose of 8000 mg quetiapine. The treatment had been initiated 3 weeks before. The current medications were lamuvidine, ritonavir, atazanavir and tenofovir for an HIV infection. The patient presented a deep coma and sustained hypotension as main complications. The toxicokinetic data revealed a markedly prolonged elimination half-life for quetiapine (62.4 hours) and the relationship with antiretroviral therapy is discussed.

Publication types

  • Case Reports

MeSH terms

  • Anti-HIV Agents / adverse effects*
  • Anti-HIV Agents / pharmacology
  • Anti-HIV Agents / therapeutic use
  • Antipsychotic Agents / pharmacokinetics
  • Antipsychotic Agents / poisoning*
  • Coma / chemically induced
  • Dibenzothiazepines / pharmacokinetics
  • Dibenzothiazepines / poisoning*
  • Drug Interactions
  • Drug Overdose
  • Female
  • HIV Infections / complications
  • HIV Infections / drug therapy
  • Half-Life
  • Humans
  • Hypotension / chemically induced
  • Middle Aged
  • Quetiapine Fumarate

Substances

  • Anti-HIV Agents
  • Antipsychotic Agents
  • Dibenzothiazepines
  • Quetiapine Fumarate