Abstract
A 47-year-old woman ingested an overdose of 8000 mg quetiapine. The treatment had been initiated 3 weeks before. The current medications were lamuvidine, ritonavir, atazanavir and tenofovir for an HIV infection. The patient presented a deep coma and sustained hypotension as main complications. The toxicokinetic data revealed a markedly prolonged elimination half-life for quetiapine (62.4 hours) and the relationship with antiretroviral therapy is discussed.
MeSH terms
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Anti-HIV Agents / adverse effects*
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Anti-HIV Agents / pharmacology
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Anti-HIV Agents / therapeutic use
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Antipsychotic Agents / pharmacokinetics
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Antipsychotic Agents / poisoning*
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Coma / chemically induced
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Dibenzothiazepines / pharmacokinetics
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Dibenzothiazepines / poisoning*
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Drug Interactions
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Drug Overdose
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Female
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HIV Infections / complications
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HIV Infections / drug therapy
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Half-Life
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Humans
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Hypotension / chemically induced
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Middle Aged
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Quetiapine Fumarate
Substances
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Anti-HIV Agents
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Antipsychotic Agents
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Dibenzothiazepines
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Quetiapine Fumarate