Point-of-care Arkansas method for measuring adherence to treatment with isoniazid

Respir Med. 2010 May;104(5):754-7. doi: 10.1016/j.rmed.2010.02.001. Epub 2010 Mar 3.


We evaluated the accuracy of a point-of-care test designed to measure adherence to isoniazid (INH) preventive therapy in a hospital setting in Rio de Janeiro, Brazil. Patients on treatment with daily INH and patients not receiving INH were included. Sensitivity and specificity of the test were 84%/98% at the first minute, and 95%/98% at the fifth minute, respectively. Among smokers, sensitivity and specificity was reduced (80%/89% at the fifth minute, respectively), but only 17% smoked. This test accurately detected INH metabolites 24h following directly observed INH intake, though sensitivity and specificity may be compromised by tobacco smoke exposure.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antitubercular Agents / administration & dosage
  • Antitubercular Agents / urine*
  • Brazil
  • Female
  • Humans
  • Isoniazid / administration & dosage
  • Isoniazid / urine*
  • Male
  • Medication Adherence*
  • Sensitivity and Specificity
  • Tuberculosis, Pulmonary / drug therapy
  • Tuberculosis, Pulmonary / urine*


  • Antitubercular Agents
  • Isoniazid