Clinical immunology: Culprits with evolutionary ties

Nature. 2010 Mar 4;464(7285):41-2. doi: 10.1038/464041a.

Abstract

The cellular organelles we know as mitochondria are thought to have originated as symbiotic bacteria. Indeed, the two use common mechanisms to trigger innate immune responses to injury and infection, respectively.

Publication types

  • News
  • Comment

MeSH terms

  • Acute Lung Injury / immunology
  • Acute Lung Injury / pathology
  • Animals
  • DNA, Mitochondrial / blood
  • DNA, Mitochondrial / immunology
  • Humans
  • Immunity, Innate / immunology*
  • Mitochondria / immunology*
  • Mitochondria / metabolism*
  • N-Formylmethionine Leucyl-Phenylalanine / immunology
  • N-Formylmethionine Leucyl-Phenylalanine / metabolism
  • Neutrophils / enzymology
  • Neutrophils / immunology
  • Sepsis / immunology
  • Sepsis / metabolism
  • Sepsis / microbiology
  • Systemic Inflammatory Response Syndrome / blood
  • Systemic Inflammatory Response Syndrome / complications*
  • Systemic Inflammatory Response Syndrome / immunology*
  • Systemic Inflammatory Response Syndrome / pathology
  • Wounds and Injuries / blood
  • Wounds and Injuries / complications*
  • Wounds and Injuries / immunology*
  • Wounds and Injuries / pathology

Substances

  • DNA, Mitochondrial
  • N-Formylmethionine Leucyl-Phenylalanine