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. 2010 Apr;23(4):1145-51.
doi: 10.3892/or_00000744.

Anti-leukaemic Effects of Two Extract Types of Lactuca Sativa Correlate With the Activation of Chk2, Induction of p21, Downregulation of Cyclin D1 and Acetylation of Alpha-Tubulin

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Anti-leukaemic Effects of Two Extract Types of Lactuca Sativa Correlate With the Activation of Chk2, Induction of p21, Downregulation of Cyclin D1 and Acetylation of Alpha-Tubulin

Manuela Gridling et al. Oncol Rep. .

Abstract

The water extract of the lettuce Lactuca sativa, but not the ethyl acetate extract, inhibited the growth of HL-60 leukaemia cells and MCF-7 breast cancer cells. This correlated with the activation of checkpoint kinase 2 (Chk2), the induction of the tumour suppressor p21, and the severe downregulation of the proto-oncogene cyclin D1. The ethyl acetate extract, but not the water extract, induced HL-60 cell death, which correlated with the acetylation of alpha-tubulin. The acetylation of alpha-tubulin is indicative for microtubuli stabilisation such as induced by taxol. The calculated amount for human intake would require approximately 3 kg lettuce to reach the required concentration shown to inhibit 50% HL-60 proliferation.

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