Mitochondrial regulation of oxygen sensing

Adv Exp Med Biol. 2010;661:339-54. doi: 10.1007/978-1-60761-500-2_22.


Hypoxia promotes physiological processes such as energy metabolism, angiogenesis, cell proliferation, and cell viability through the transcription factor Hypoxia Inducible Factor (HIF). Hypoxia also diminishes the activity of ATP consuming processes to promote cell survival. The mechanism(s) by which hypoxia activates HIF and diminishes ATP demand are a subject of intensive research. Here we outline the model in which mitochondrial complex III regulate the activity of HIF and diminish ATP utilization processes through the increased production of ROS during hypoxia.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Animals
  • Electron Transport / physiology
  • Hypoxia / metabolism
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism*
  • Mitochondria / metabolism*
  • Oxygen / metabolism*
  • Procollagen-Proline Dioxygenase / metabolism
  • Reactive Oxygen Species / metabolism
  • Sodium-Potassium-Exchanging ATPase / metabolism
  • Ubiquinone / metabolism


  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Reactive Oxygen Species
  • Ubiquinone
  • Adenosine Triphosphate
  • Procollagen-Proline Dioxygenase
  • Sodium-Potassium-Exchanging ATPase
  • Oxygen