Effects of treatment with once-daily nifedipine CR and twice-daily benidipine on prevention of symptomatic attacks in patients with coronary spastic angina pectoris-Adalat Trial vs Coniel in Tokyo against Coronary Spastic Angina (ATTACK CSA)

J Cardiol. 2010 Mar;55(2):238-47. doi: 10.1016/j.jjcc.2009.11.005. Epub 2010 Jan 14.


Background: We compared the efficacy of once-daily treatment with nifedipine CR 40 mg (NR) and twice-daily treatment with benidipine 4 mg (BD) in patients with coronary spastic angina (CSA) registered in 3 cardiovascular institutes in Tokyo.

Methods and results: CSA was diagnosed by an ischemic ST change during Holter ECG monitoring or drug-induced test. Thirty patients were randomly allocated to either NR or BD group. The number of symptomatic attacks and the total frequency of short-acting nitrates were examined based on the data in diaries written by patients. There were no significant differences in the baseline characteristics between the two groups. The median number (25-75% quartile) of attacks per week was significantly decreased in NR group, i.e., 1.0 (0.8-2.0) at baseline, 0.0 (0.0-1.0) after 4 weeks of treatment, and 0.0 (0.0-0.0) after 8 weeks of treatment (P=0.0093, P=0.0002, Wilcoxon's rank-sum test). No significant decrease was observed in BD, i.e. 1.0 (0.5-2.0) at baseline, 1.3 (0.0-3.0) after 4 weeks, and 0.0 (0.0-1.0) after 8 weeks. The number of attacks was fewer in NR than in BD group (P=0.074, P=0.015, U-test for difference).

Conclusion: Once-daily treatment with NR 40 mg was more effective than twice-daily treatment with BD in the prevention of CSA attacks.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Acetylcholine
  • Angina Pectoris / prevention & control*
  • Blood Pressure / drug effects
  • Coronary Vasospasm / chemically induced
  • Coronary Vasospasm / prevention & control*
  • Dihydropyridines / administration & dosage*
  • Electrocardiography, Ambulatory
  • Ergonovine
  • Female
  • Heart Rate / drug effects
  • Humans
  • Male
  • Middle Aged
  • Nifedipine / administration & dosage*
  • Nitrates / therapeutic use
  • Vasodilator Agents / administration & dosage*


  • Dihydropyridines
  • Nitrates
  • Vasodilator Agents
  • benidipine
  • Nifedipine
  • Acetylcholine
  • Ergonovine