Heterologous expression of the oxytetracycline biosynthetic pathway in Myxococcus xanthus

Appl Environ Microbiol. 2010 Apr;76(8):2681-3. doi: 10.1128/AEM.02841-09. Epub 2010 Mar 5.


New natural products for drug discovery may be accessed by heterologous expression of bacterial biosynthetic pathways in metagenomic DNA libraries. However, a "universal" host is needed for this experiment. Herein, we show that Myxococcus xanthus is a potential "universal" host for heterologous expression of polyketide biosynthetic gene clusters.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / biosynthesis*
  • Bacterial Proteins / genetics*
  • Biosynthetic Pathways / genetics*
  • Gene Order
  • Multigene Family
  • Myxococcus xanthus / genetics*
  • Oxytetracycline / biosynthesis*
  • Recombinant Proteins / biosynthesis
  • Recombinant Proteins / genetics


  • Bacterial Proteins
  • Recombinant Proteins
  • Oxytetracycline