Structure of native laccase B from Trametes sp. AH28-2

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Mar 1;66(Pt 3):254-8. doi: 10.1107/S1744309110000084. Epub 2010 Feb 23.


Fungal laccases are oxidoreductases that belong to the multinuclear copper-containing oxidases. They are able to oxidize a wide range of substrates, preferably phenolic compounds, which makes them suitable for employment in the bioremediation of soil and water as well as in other biotechnological applications. Here, the structural analysis of natural laccase B (LacB) from Trametes sp. AH28-2 is presented. This structure provides the opportunity to study the natural post-translational modifications of the enzyme. The overall fold shows a high homology to those of previously analyzed laccases with known three-dimensional structure. However, LacB contains a new structural element, a protruding loop near the substrate-binding site, compared with the previously reported laccase structures. This unique structural feature may be involved in modulation of the substrate recognition of LacB.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Binding Sites
  • Conserved Sequence
  • Crystallography, X-Ray
  • Laccase / chemistry*
  • Laccase / metabolism
  • Molecular Sequence Data
  • Protein Stability
  • Sequence Alignment
  • Structural Homology, Protein
  • Substrate Specificity
  • Trametes / enzymology*


  • Laccase

Associated data

  • PDB/3KW7