Use of autologous whole blood during internal limiting membrane peeling and macular hole surgery is protective for indocyanine green toxicity

Cutan Ocul Toxicol. 2010 Jun;29(2):98-104. doi: 10.3109/15569521003627867.


Objective: To compare indocyanine green (ICG)-assisted internal limiting membrane (ILM) peeling with and without autologous whole blood (WB) protection during macular hole repair surgery.

Material and methods: We retrospectively reviewed 50 eyes with an idiopathic macular hole. Group 1 contained 22 eyes that underwent ILM peeling with WB protection and group 2 contained 28 eyes that underwent ILM peeling without WB. Anatomic and visual results were compared.

Results: After surgery, macular hole closure was achieved in 96% of the group 1 eyes and in 93% of the group 2 eyes. The preoperative mean best-corrected visual acuity (BCVA) was logarithm of the minimum angle of resolution (logMAR) 0.95 in group 1 and logMAR 0.89 in group 2 (p = .544). The postoperative mean BCVA was logMAR 0.57 in group 1 and logMAR 0.92 in group 2 (p = .017).

Conclusion: Macular hole surgery protected with WB facilitates improved visual recovery in ICG-assisted ILM peeling.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Transfusion, Autologous*
  • Female
  • Humans
  • Indocyanine Green / toxicity*
  • Male
  • Membranes / pathology
  • Ophthalmologic Surgical Procedures / methods*
  • Retinal Perforations / pathology
  • Retinal Perforations / surgery*
  • Retinal Pigment Epithelium / pathology
  • Retrospective Studies
  • Treatment Outcome
  • Visual Acuity


  • Indocyanine Green