TB: screening for responses to a vile visitor

Cell. 2010 Mar 5;140(5):615-8. doi: 10.1016/j.cell.2010.02.030.


Mycobacteria, the pathogens that cause tuberculosis and leprosy, establish long-term infections in host macrophages. Recent studies, including two genetic screens reported in this issue of Cell (Kumar et al., 2010; Tobin et al., 2010), reveal that virulent mycobacteria evade the host immune system by stimulating production of anti-inflammatory molecules and inhibiting autophagy.

Publication types

  • Review

MeSH terms

  • Animals
  • Autophagy
  • Genetic Predisposition to Disease
  • Humans
  • Immune Evasion
  • Macrophages / immunology*
  • Macrophages / microbiology
  • Mycobacterium tuberculosis / immunology*
  • Tuberculosis / genetics
  • Tuberculosis / immunology*
  • Tuberculosis / microbiology