The regulation and turnover of mitochondrial uncoupling proteins

Biochim Biophys Acta. Jun-Jul 2010;1797(6-7):785-91. doi: 10.1016/j.bbabio.2010.02.035. Epub 2010 Mar 6.


Uncoupling proteins (UCP1, UCP2 and UCP3) are important in regulating cellular fuel metabolism and as attenuators of reactive oxygen species production through strong or mild uncoupling. The generic function and broad tissue distribution of the uncoupling protein family means that they are increasingly implicated in a range of pathophysiological processes including obesity, insulin resistance and diabetes mellitus, neurodegeneration, cardiovascular disease, immunity and cancer. The significant recent progress describing the turnover of novel uncoupling proteins, as well as current views on the physiological roles and regulation of UCPs, is outlined.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus / metabolism
  • Energy Metabolism
  • Gene Expression
  • Humans
  • Insulin Resistance
  • Ion Channels / genetics
  • Ion Channels / metabolism*
  • Mitochondria / metabolism
  • Mitochondrial Proteins / genetics
  • Mitochondrial Proteins / metabolism*
  • Models, Biological
  • Obesity / metabolism
  • Uncoupling Protein 1
  • Uncoupling Protein 2
  • Uncoupling Protein 3


  • Ion Channels
  • Mitochondrial Proteins
  • UCP1 protein, human
  • UCP2 protein, human
  • UCP3 protein, human
  • Uncoupling Protein 1
  • Uncoupling Protein 2
  • Uncoupling Protein 3