A view from Drosophila: multiple biological functions for individual microRNAs

Semin Cell Dev Biol. 2010 Sep;21(7):745-53. doi: 10.1016/j.semcdb.2010.03.001. Epub 2010 Mar 6.


microRNAs (miRNAs) comprise an extensive class of post-transcriptional regulatory molecules in higher eukaryotes. Intensive research in Drosophila has revealed that miRNAs control myriad developmental and physiological processes. Interestingly, several of the best-studied miRNAs impact multiple biological processes, often by regulating distinct key target genes in each setting. Here we discuss the roles of some of these pleiotropic miRNAs, and their implications for studying and interpreting the roles of miRNAs in gene regulatory networks.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Drosophila / genetics
  • Drosophila / physiology*
  • Gene Regulatory Networks
  • Genetic Pleiotropy
  • MicroRNAs / genetics
  • MicroRNAs / physiology*


  • MicroRNAs