Conditions that mimic osteosarcoma

Cancer Treat Res. 2009:152:85-121. doi: 10.1007/978-1-4419-0284-9_5.


A variety of conditions may mimic osteosarcoma. The differential diagnosis includes benign and malignant tumors, infection and inflammatory processes arising from the musculoskeletal system. An accurate clinical history, imaging studies, and pathological evaluation are essential to establish the exact diagnosis. This chapter describes many of the conditions which may mimic the diagnosis of osteosarcoma. For convenience, the conditions are divided into several categories.

Publication types

  • Review

MeSH terms

  • Bone Cysts, Aneurysmal / diagnosis
  • Bone Neoplasms / diagnosis*
  • Chondrosarcoma / diagnosis
  • Diagnosis, Differential
  • Fibroma, Ossifying / diagnosis
  • Giant Cell Tumor of Bone / diagnosis
  • Humans
  • Osteosarcoma / diagnosis*
  • Sarcoma, Ewing / diagnosis