Biological activity of phenolic lipids

Cell Mol Life Sci. 2010 Mar;67(6):841-60. doi: 10.1007/s00018-009-0193-1.

Abstract

Phenolic lipids are a very diversified group of compounds derived from mono and dihydroxyphenols, i.e., phenol, catechol, resorcinol, and hydroquinone. Due to their strong amphiphilic character, these compounds can incorporate into erythrocytes and liposomal membranes. In this review, the antioxidant, antigenotoxic, and cytostatic activities of resorcinolic and other phenolic lipids are described. The ability of these compounds to inhibit bacterial, fungal, protozoan and parasite growth seems to depend on their interaction with proteins and/or on their membrane-disturbing properties.

Publication types

  • Review

MeSH terms

  • Animals
  • Antimutagenic Agents / chemistry
  • Antimutagenic Agents / metabolism
  • Antimutagenic Agents / pharmacology*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology*
  • Antioxidants / chemistry
  • Antioxidants / metabolism
  • Antioxidants / pharmacology*
  • Humans
  • Lipids / chemistry
  • Lipids / pharmacology*
  • Phenol / chemistry
  • Phenol / metabolism
  • Phenol / pharmacology*

Substances

  • Antimutagenic Agents
  • Antineoplastic Agents
  • Antioxidants
  • Lipids
  • Phenol