Objective: To clarify the correlation between primary gout and insulin-resistance (IR), and to observe the effect of serial gout granules (SGGs) on IR in patients with primary gout.
Methods: Pearson's correlation analysis and multiple stepwise correlation analysis were conducted between 60 patients and 60 healthy volunteers in terms of blood pressure (BP), blood levels of uric acid (sUA), fasting plasma glucose (FPG), fasting insulin (FINS), fasting leptin (FL), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and C-peptide (CP), body mass index (BMI), waist-to-hip ratio (WHR), insulin resistance index (IRI) and insulin sensitivity index (ISI). Besides, the 60 primary gout patients were equally randomized into two groups, the treatment group treated with SGGs (huzhang gout granule and yinlian gout granule), and the control group treated with diclofenac sodium dual release enteric-coated capsules and Benzbromarone. bove-mentioned indexes in them were assessed before and after 12 weeks of treatment.
Results: The levels of sUA, FPG, TC, TG, LDL-C, FINS, CP, FL, IRI, BMI, and WHR were higher while the levels of HDL-C and ISI was lower in gout patients than those in healthy controls (all P < 0.05); Pearson's correlation analysis showed that level of sUA was positively correlated with levels of FPG, FINS, IRI, BMI, TC, TG, LDL-C, CP, FL, systolic pressure and diastolic pressure (r = 0.444, 0.496, 0.660, 0.542, 0.414, 0.467, 0.344, 0.470, 0.419, 0.275, 0.330 respectively, P < 0.05), but negatively correla- ted with levels of ISI and HDL-C (r = -0.569, -0.264 respectively, P < 0.05). Multiple stepwise correlation analysis showed that sUA was also positively correlated with IRI, TG and BMI (r = 5.758, 2.849, 3. 425 respectively, P < 0.05). After 12 weeks of treatment, the lowed range of TC, TG, FINS, FPG and IRI, and the increased amplitude of HDL-C and ISI in the treatment group were superior to those in the control group respectively (P < 0.05).
Conclusion: Patients with primary gout are low in insulin sensitivity and indicating the existence of IR. SGGs could enhance patients' insulin sensitivity and improve IR to a certain extent.