The molecular pathogenesis of Ewing's sarcoma

Cancer Biol Ther. 2010 May 1;9(9):655-67. doi: 10.4161/cbt.9.9.11511. Epub 2010 May 12.


Ewing sarcoma family tumors (ESFT) are a group of aggressive solid bone and soft tissue malignancies of children and young adults characterized by specific chromosomal translocations that give rise to EWS-ETS aberrant transcription factors. Identification of EWS-ETS target genes and their role in tumor signaling networks together with the unravelling of the cell of origin will facilitate the translation into new treatment modalities for these neoplasms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Sarcoma, Ewing / etiology*
  • Sarcoma, Ewing / physiopathology
  • Signal Transduction / physiology